[PDF] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. | Semantic Scholar (2024)

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@article{Sarris2019LtheanineIT, title={L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.}, author={Jerome Sarris and Gerard J. Byrne and Lachlan Cribb and Georgina Oliver and Jenifer A Murphy and Patricia Macdonald and Sonia Nazareth and Diana Karamacoska and Samantha Galea and Anika Short and Carolyn C Ee and Yoann Birling and Ranjit Menon and Chee H. Ng}, journal={Journal of psychiatric research}, year={2019}, volume={110}, pages={ 31-37 }, url={https://api.semanticscholar.org/CorpusID:58601994}}
  • J. Sarris, G. Byrne, C. Ng
  • Published in Journal of Psychiatric… 1 March 2019
  • Medicine

31 Citations

Highly Influential Citations

2

Background Citations

11

Methods Citations

2

Results Citations

1

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31 Citations

Psychotropic effects of L-theanine and its clinical properties: from the management of anxiety and stress to a potential use in schizophrenia.
    Filipe Lopes SakamotoRodrigo Metzker Pereira RibeiroAllain Amador BuenoHeitor Oliveira Santos

    Medicine, Psychology

    Pharmacological research

  • 2019
  • 30
  • PDF
The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review
    Jackson WilliamsJulian Everett N. Naumovski

    Medicine

    Plant Foods for Human Nutrition

  • 2019

It is suggested that supplementation of 200–400mg/day of L-THE may assist in the reduction of stress and anxiety in people exposed to stressful conditions.

Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study
    Madhuri S. KurdiAthira AsD. LadhadM. MitragotriAmritha Baiju

    Medicine

    Indian journal of palliative care

  • 2024

The hypnotic efficacy of oral melatonin 3 mg was better than oral L-theanine 200 mg in cancer patients having insomnia, and L-theanine had a better hypnotic efficacy when compared to a placebo.

Medicinal herbs for the treatment of anxiety: a systematic review and network meta-analysis.
    Wenting ZhangYonghuan Yan Zeqi Su

    Medicine

    Pharmacological research

  • 2022
  • 18
    V. BorgonettiP. GovernaM. BiagiN. Galeotti

    Medicine

    Nutrients

  • 2020

TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which was related to a neuroprotective effect in an in vitro model of excitotoxicity, suggesting a non-benzodiazepine-like mechanism of action.

L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study
    T. DassanayakeC. KahathuduwaV. Weerasinghe

    Medicine

    Nutritional neuroscience

  • 2020

The findings indicate L-theanine can increase attentional processing of auditory information in a dose-dependent manner, and the linear dose–response attentional effects observed warrant further studies with higher doses of L- theanine.

  • 4
Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study
    R. RizzoAdriana PratoMiriam ScerboFederica SaiaR. BaroneP. Curatolo

    Medicine

    Nutrients

  • 2022

Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and co-occurring disorders. It has been suggested that anxiety occurs in 2–45% patients affected by Tourette

A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave®l-Theanine on Stress in a Healthy Adult Population
    M. EvansAlison C. McDonaldLora XiongDavid C. CrowleyN. Guthrie

    Medicine, Psychology

    Neurology and Therapy

  • 2021

A single dose of AlphaWave®l-Theanine significantly increased frontal region alpha power compared to placebo in response to an acute stress challenge and was found to be safe and well tolerated by participants.

  • 5
  • PDF
Soft Drinks and Symptoms of Depression and Anxiety in Overweight Subjects: A Longitudinal Analysis of an European Cohort
    A. CastroM. Gili Miquel Roca

    Medicine

    Nutrients

  • 2023

The high and regular consumption of carbonated/soft drink with sugar tended to be associated with higher level of anxiety in a multicountry sample of overweight subjects with subsyndromal depressive symptoms.

Diet and Anxiety: A Scoping Review
    Monique AucoinL. Lachance K. Cooley

    Medicine, Agricultural and Food Sciences

    Nutrients

  • 2021

This scoping review sought to systematically map the existing literature on anxiety disorders and nutrition in order to identify associations between dietary factors and anxiety symptoms or disorder prevalence as well as identify gaps and opportunities for further research.

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35 References

L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    M. RitsnerC. Miodownik V. Lerner

    Medicine, Psychology

    The Journal of clinical psychiatry

  • 2011

L-theanine augmentation of antipsychotic therapy can ameliorate positive, activation, and anxiety symptoms in schizophrenia and schizoaffective disorder patients.

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  • PDF
Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study
    S. HideseM. Ota H. Kunugi

    Medicine

    Acta Neuropsychiatrica

  • 2016

It is suggested that chronic (8-week) l-theanine administration is safe and has multiple beneficial effects on depressive symptoms, anxiety, sleep disturbance and cognitive impairments in patients with MDD.

  • 63
  • Highly Influential
  • PDF
The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.
    M. LyonM. KapoorL. Juneja

    Medicine

    Alternative medicine review : a journal of…

  • 2011

Since sleep problems are a common co-morbidity associated with ADHD, and because disturbed sleep may be linked etiologically to this disorder, L-theanine may represent a safe and important adjunctive therapy in childhood ADHD.

  • 61
  • PDF
The acute effects of L‐theanine in comparison with alprazolam on anticipatory anxiety in humans
    Kristy LuM. Gray P. Nathan

    Medicine, Psychology

    Human psychopharmacology

  • 2004

It is suggested that while L‐ theanine may have some relaxing effects under resting conditions, neither L‐theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model.

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Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.
    J. SarrisJenifer A Murphy C. Ng

    Medicine

    The American journal of psychiatry

  • 2016

Current evidence supports adjunctive use of SAMe, methylfolate, omega-3, and vitamin D with antidepressants to reduce depressive symptoms.

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Pharmacological treatment of generalized anxiety disorder
    J. ReinholdL. MandosK. RickelsF. Lohoff

    Medicine, Psychology

    Expert opinion on pharmacotherapy

  • 2011

Current pharmacological treatment options for GAD are described, with focus on benzodiazepines, azapirones, antidepressants and anticonvulsant and antipsychotic drugs.

  • 53
Effect of l-theanine on glutamatergic function in patients with schizophrenia
    M. OtaC. Wakabayashi H. Kunugi

    Medicine

    Acta Neuropsychiatrica

  • 2015

The MRS findings suggest that l-theanine stabilises the glutamatergic concentration in the brain, which is a possible mechanism underlying the therapeutic effect of l- theanine in schizophrenia.

  • 37
Pharmacological treatment for generalized anxiety disorder in adults: an update
    J. ReinholdK. Rickels

    Medicine

    Expert opinion on pharmacotherapy

  • 2015

Based on the evidence available to us, it is recommended that along with the ADs, benzodiazepines be considered a possible first-line therapy in eligible patients based on the discretion and clinical judgment of the treating physician.

  • 77
Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress
    K. UnnoNaoki Tanida H. Yamada

    Medicine

    Pharmacology Biochemistry and Behavior

  • 2013
  • 58
Cognitive behavioral therapy for anxiety and related disorders: A meta‐analysis of randomized placebo‐controlled trials
    Joseph K. CarpenterLeigh A AndrewsS. WitcraftMark B. PowersJasper A. J. SmitsS. Hofmann

    Psychology

    Depression and anxiety

  • 2018

It is demonstrated that CBT is a moderately efficacious treatment for anxiety disorders when compared to placebo, and more effective treatments are especially needed for PTSD, SAD, and PD.

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    [PDF] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. | Semantic Scholar (2024)

    FAQs

    What is the 3-3-3 rule for anxiety? ›

    You can use the 333 rule for anxiety in the moment something triggers you. Just look around to identify 3 objects and 3 sounds, then move 3 body parts. Many people find this strategy helps focus and ground them when anxiety seems overwhelming. The 333 rule is a common and informal technique for coping with anxiety.

    Does L-theanine help GAD? ›

    Research suggests that taking L-theanine for anxiety can help reduce stress while promoting relaxation. If you are diagnosed with generalized anxiety disorder or dealing with anxiety symptoms and looking for a natural remedy, you can learn more about L-theanine here.

    Which is better for anxiety, gaba or L-theanine? ›

    Research shows that L-theanine supplements can elevate your levels of GABA, dopamine and serotonin, which promotes relaxation and reduces anxiety levels. A randomized trial from 2019 found that healthy adults who took L-theanine over the course of four weeks had a decrease in stress-related symptoms.

    What is the best medication for GAD? ›

    Selective serotonin reuptake inhibitors (SSRIs) are among the most preferred generalized anxiety disorder medications. 4 This class of antidepressants includes medications such as Lexapro (escitalopram), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline).

    What is the 5 5 5 rule for anxiety? ›

    Root the body and mind with grounding techniques

    Similar is the 5 5 5 rule where you breathe in deeply for 5 seconds, hold the breath for 5 seconds, and breathe out for 5 seconds. Then, identify five things you can see, five sounds you hear, and five objects around you that you can touch.

    What is the 5 4 3 2 1 anxiety trick? ›

    5, 4, 3, 2, 1 exercise for anxiety FAQs

    It involves identifying 5 things you can see, 4 things you can touch, 3 things you can hear, 2 things you can smell, and 1 thing you can taste. By doing so, it helps shift your focus from anxiety-provoking thoughts to the present moment.

    What are the negative side effects of L-theanine? ›

    High doses on daily basis will lead to:
    • Lowering blood pressure (which may be beneficial to some people).
    • Appetite loss.
    • Diarrhea.>
    • Difficulty in concentration.
    • Headache.
    • Nausea.
    • Extreme high doses (29mg/kg/day) can cause liver toxicity.

    How much L-theanine per day for severe anxiety? ›

    The recommended daily intake of l-theanine for anxiety is about 200 to 400 mg daily. Ensure you take the dosage as advised by your doctor, as a higher dosage of over 1200 mg can lead to severe side effects. L-theanine can be combined with other substances to improve its effects on anxiety.

    Which is better for anxiety 5 HTP or L-theanine? ›

    5-HTP has an average rating of 6.5 out of 10 from a total of 155 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. L-theanine has an average rating of 5.4 out of 10 from a total of 142 ratings on Drugs.com.

    How long does it take L-theanine to kick in? ›

    However, the original claims relating to the calming effect of l-theanine show it is usually noted within 40–60 min after l-theanine ingestion at a dose of 50–200 mg. Effective dose of 200 mg of l-theanine in the present study to induce relaxation is well consistent with the work of Kobayashi et al.

    What medications should not be taken with L-theanine? ›

    L-theanine may interact with the following drugs and supplements:
    • drugs for the treatment of high blood pressure.
    • other supplements that lower blood pressure.
    • stimulants, such as those that doctors use to treat attention deficit hyperactivity disorder (ADHD)
    • supplements that contain caffeine.

    Is ashwagandha or L-theanine better for stress? ›

    While L-theanine helps you relax when you need to give yourself a time out, ashwagandha helps you keep from getting all worked up in the first place! Indeed, ashwagandha is practically the poster child of adaptogens (substances that help support healthy stress response and cortisol levels).

    What is the new treatment for generalized anxiety disorder? ›

    LSD-Based Medication for GAD Receives FDA Breakthrough Status. The US Food and Drug Administration (FDA) has granted breakthrough designation to an LSD-based treatment for generalized anxiety disorder (GAD) based on promising topline data from a phase 2b clinical trial.

    What is the number one drug for anxiety? ›

    The most prominent of anti-anxiety drugs for the purpose of immediate relief are those known as benzodiazepines; among them are alprazolam (Xanax), clonazepam (Klonopin), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan).

    What is the best therapy for generalized anxiety disorder? ›

    One of the most effective types of therapy for anxiety is cognitive behavioral therapy (CBT). And new research suggests that intensive CBT programs with short bursts of daily treatment can be just as effective as the traditional 12 to 20 weeks of weekly therapy.

    What are the 4 C's of anxiety? ›

    More specifically we expect positive association between caring and anxiety and a negative association between the other four Cs (competence, confidence, character, and connection) and anxiety.

    What are the 3 C's of anxiety? ›

    The Three C's for Anxiety. When it comes to coping with anxiety, the three C's - Calm Techniques, Coping Strategies, and Communication Skills - can be powerful tools in managing and reducing anxiety symptoms.

    What is the number one way to get rid of anxiety? ›

    Natural strategies like regular physical activity, aromatherapy, deep breathing, mindfulness, and chamomile tea may help you reduce anxiety symptoms. If you feel your anxiety is getting worse, consider professional help. Talk therapy, prescription medication, or both, may help with severe or persistent anxiety.

    What are the 3 P's of anxiety? ›

    The 3 P's stand for Pervasiveness, Permanence and Personalisation. Pervasiveness looks at how much of your life a concern impacts – How big? Permanence looks at how long an issue is going to be of concern – How long? Personalisation looks at how much you feel you are to blame – How much?

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